Made with natural ingredients, GLOWELLE is a dietary supplement beauty drink that delivers high quality, skin-beautifying nutrients to the inner and outer layers of your skin.
See the list of studies conducted on the ingredients that can be found in GLOWELLE.
Afaq F, Malik A, Syed D, Maes D, Matsui MS & Mukhtar H (2005) Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol 81(1):38-45.
Ashida Y, Yamanishi H, Terada T, Oota N, Sekine K & Watabe K (2005) CoQ10 supplementation elevates the epidermal CoQ10 level in adult hairless mice. Biofactors 25(1-4):175-8.
Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian DA, Pathak MA & González S (2007) Dietary lutein/zeaxanthin partially reduces photoaging and photocarcinogenesis in chronically UVB-irradiated Skh-1 hairless mice. Skin Pharmacol Physiol 20(6):283-91.
Baliga MS, Wang H, Zhuo P, Schwartz JL & Diamond AM (2007) Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage. Biol Trace Elem Res 115(3):227-42.
Burk RF, Norsworthy BK, Hill KE, Motley AK & Byrne DW (2006) Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 15(4):804-10.
Burke KE, Clive J, Combs GF Jr & Nakamura RM (2003) Effects of topical L-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. J Am Acad Dermatol 49(3):458-72.
Césarini JP, Michel L, Maurette JM, Adhoute H & Béjot M (2003) Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed 19(4):182-9.
Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE & Kimball AB (2005) Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg 31(7 Pt 2):855-60.
Chow HH, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, Dorr RT, Hara Y & Alberts DS (2003) Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res 9(9):3312-9.
Clark LC, Combs GF Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL Jr, Park HK, Sanders BB Jr, Smith CL & Taylor JR (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 25;276(24):1957-63.
Clarke MW, Ward NC, Wu JH, Hodgson JM, Puddey IB & Croft KD (2006) Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. Am J Clin Nutr 83(1):95-102.
Davis PA, Polagruto JA, Valacchi G, Phung A, Soucek K, Keen CL & Gershwin ME (2006) Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells. Exp Biol Med (Maywood) 231(5):594-8.
de Luca C, Deeva I, Mikhal'Chik E & Korkina L (2007) Beneficial effects of pro-/antioxidant-based nutraceuticals in the skin rejuvenation techniques. Cell Mol Biol (Noisy-le-grand) 15;53(1):94-101.
Devaraj S & Jialal I (2005) Failure of vitamin E in clinical trials: is gamma-tocopherol the answer? Nutr Rev 63(8):290-3.
Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P & Jialal I (2002) Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37(10):931-4.
Dietrich M, Traber MG, Jacques PF, Cross CE, Hu Y & Block, G (2006) Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr 25(4):292-9.
Ding M, Lu Y, Bowman L, Huang C, Leonard S, Wang L, Vallyathan V, Castranova V & Shi X Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract. J Biol Chem 279(11):10670-6.
Ekanayake-Mudiyanselage S, Kraemer K & Thiele JJ (2004) Oral supplementation with all-Rac- and RRR-alpha-tocopherol increases vitamin E levels in human sebum after a latency period of 14-21 days. Ann NY Acad Sci 1031:184-94.
Enomoto T, Nagasako-Akazome Y, Kanda T, Ikeda M & Dake Y (2006) Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol 16(5):283-9.
Erden Inal M, Kahraman A & Köken T (2001) Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol 26(6):536-9.
Erden Inal M & Kahraman A (2000) The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats. Toxicology 154(1-3):21-9.
Fakih MG, Pendyala L, Smith PF, Creaven PJ, Reid ME, Badmaev V, Azrak RG, Prey JD, Lawrence D & Rustum YM (2006) A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors. Clin Cancer Res 12(4):1237-44.
Fischer JL, Mihelc EM, Pollok KE & Smith ML (2007) Chemotherapeutic selectivity conferred by selenium: a role for p53-dependent DNA repair. Mol Cancer Ther 6(1):355-61.
Fuchs J & Kern H (1998) Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med (9):1006-12.
Fuller B, Smith D, Howerton A & Kern D (2006) Anti-inflammatory effects of CoQ10 and colorless carotenoids. J Cosmet Dermatol 5(1):30-8.
González S, Astner S, An W, Goukassian D & Pathak MA (2003) Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. J Invest Dermatol 121(2):viii.
Greul AK, Grundmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A, Biesalski HK, Gollnick H (2002) Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol 15(5):307-15.
Heinrich U, Neukam K, Tronnier H, Sies H & Stahl W (2006) Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr 136(6):1565-9.
Heinrich U, Tronnier H, Stahl W, Béjot M & Maurette JM (2006) Antioxidant supplements improve parameters related to skin structure in humans. Skin Pharmacol Physiol 19(4):224-31.
Heinrich U, Gärtner C, Wiebusch M, Eichler O, Sies H, Tronnier H & Stahl W (2003) Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr 133(1):98-101.
Institute of Medicine, Dietary Reference Intakes. www.iom.edu
Jiang Q, Christen S, Shigenaga MK & Ames BN (2001) Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74(6):714-22.
Kasai K, Yoshimura M, Koga T, Arii M & Kawasaki S (2006) Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin. J Nutr Sci Vitaminol (Tokyo) 52(5):383-8.
Katiyar S, Elmets CA & Katiyar SK (2006) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. J Nutr Biochem Epub ahead of print.
Kim SY, Kim DS, Kwon SB, Park ES, Huh CH, Youn SW, Kim SW & Park KC (2005) Protective effects of EGCG on UVB-induced damage in living skin equivalents. Arch Pharm Res 28(7):784-90.
Kobayashi S (2006) UVB-induced skin damage and the protection/treatment--effects of a novel, hydrophilic gamma-tocopherol derivative. Yakugaku Zasshi 126(9):677-93.
Kootstra A (1994) Protection from UV-B-induced DNA damage by flavonoids. Plant Mol Biol 26(2):771-4.
Kundu JK, Surh YJ (2007) Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK. Ann N Y Acad Sci 1095:504-12.
Lee JH, Chung JH & Cho KH (2005) The effects of epigallocatechin-3-gallate on extracellular matrix metabolism. J Dermatol Sci 40(3):195-204.
Lee EH, Faulhaber D, Hanson KM, Ding W, Peters S, Kodali S & Granstein RD (2004) Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. J Invest Dermatol 122(2):510-7.
Lee J, Jiang S, Levine N & Watson RR (2000) Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc Soc Exp Biol Med 223(2):170-4.
Leu SJ, Lin YP, Lin RD, Wen CL, Cheng KT, Hsu FL & Lee MH (2006) Phenolic constituents of Malus doumeri var. formosana in the field of skin care. Biol Pharm Bull 29(4):740-5.
Li XM, Ma YL & Liu XJ (2007) Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice J Ethnopharmacol 111(3):504-11.
Luo D, Min W, Lin XF, Wu D, Xu Y & Miao X (2006) Effect of epigallocatechingallate on ultraviolet B-induced photo-damage in keratinocyte cell line. Am J Chin Med 34(5):911-22.
Luo H, Tang L, Tang M, Billam M, Huang T, Yu J, Wei Z, Liang Y, Wang K, Zhang ZQ, Zhang L & Wang JS (2006) Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 27(2):262-8.
Mantena SK & Katiyar SK (2006) Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes. Free Radic Biol Med 40(9):1603-14.
Meeran SM, Mantena SK, Elmets CA & Katiyar SK (2006) (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res 66(10):5512-20.
Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L & Derendorf H (2006) Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem 54(23):8956-61.
Mireles-Rocha H, Galindo I, Huerta M, Trujillo-Hernández B, Elizalde A & Cortés-Franco R (2002) UVB photoprotection with antioxidants: effects of oral therapy with d-alpha-tocopherol and ascorbic acid on the minimal erythema dose. Acta Derm Venereol 82(1):21-4.
Mittal A, Elmets CA & Katiyar SK (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24(8):1379-88.
Nam NH (2006) Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem. 6(8):945-51.
Moon HI, Lee J, Zee OP & Chung JH (2005) The effect of flavonol glycoside on the expressions of matrix metalloproteinase-1 in ultraviolet-irradiated cultured human skin fibroblasts. J Ethnopharmacol 101(1-3):176-9.
Morley N, Clifford T, Salter L, Campbell S, Gould D & Curnow A. (2005) The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage. Photodermatol Photoimmunol Photomed.21(1):15-22.
Neukam K, Stahl W, Tronnier H, Sies H, Heinrich U. 2007Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr 46(1):53-6.
Ni Z, Mu Y & Gulati O (2002) Treatment of melasma with Pycnogenol. Phytother Res 16(6):567-71.
Nuttall SL, Kendall MJ, Bombardelli E & Morazzoni P (1998) An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23(5):385-9.
Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R & Morganti P (2007) Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol 20(4):199-210.
Passi S, De Pità O, Puddu P & Littarru GP (2002) Lipophilic antioxidants in human sebum and aging. Free Radic Res 36(4):471-7.
Placzek M, Gaube S, Kerkmann U, Gilbertz KP, Herzinger T & Haen E, Przybilla B (2005) Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol. J Invest Dermatol 124(2):304-7.
Reid ME, Stratton MS, Lillico AJ, Fakih M, Natarajan R, Clark LC & Marshall JR (2004) A report of high-dose selenium supplementation: response and toxicities. J Trace Elem Med Biol 18(1):69-74.
Ribaya-Mercado JD, Garmyn M, Gilchrest BA & Russell RM (1995) Skin lycopene is destroyed preferentially over beta-carotene during ultraviolet irradiation in humans. J Nutr 125(7):1854-9.
Richelle M, Sabatier M, Steiling H & Williamson G (2006) Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr 96(2):227-38.
Rusciani L, Proietti I, Paradisi A, Rusciani A, Guerriero G, Mammone A, De Gaetano A & Lippa S Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. Melanoma Res 17(3):177-83.
Rusciani L, Proietti I, Rusciani A & Paradisi A (2006) Sbordoni G, Alfano C, Panunzi S, De Gaetano A, Lippa S. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol 54(2):234-41.
Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR & Packer L (2001) Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 30(2):154-60.
Schäfer A, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z & Högger P (2006) Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother 60(1):5-9.
Segger D & Schönlau F (2004) Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat 15(4):222-6.
Sharma SD & Katiyar SK (2006) Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. Carcinogenesis 27(1):95-102.
Shoji T, Masumoto S, Moriichi N, Kobori M, Kanda T, Shinmoto H & Tsushida T (2005) Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J Agric Food Chem 53(15):6105-11.
Sim GS, Lee BC, Cho HS, Lee JW, Kim JH, Lee DH, Kim JH, Pyo HB, Moon DC, Oh KW, Yun YP & Hong JT (2007) Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharm Res 30(3):290-8.
Sin BY & Kim HP (2005) Inhibition of collagenase by naturally-occurring flavonoids. Arch Pharm Res 28(10):1152-5.
Skovgaard GR, Jensen AS & Sigler ML (2006) Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 60(10):1201-6.
Stahl W, Heinrich U, Aust O, Tronnier H & Sies H (2006) Lycopene-rich products and dietary photoprotection. Photochem Photobiol Sci 5(2):238-42.
Stahl W & Sies H. (2002) Cartenoids and protection against solar UV radiation. Skin Pharmacol Appl Skin Physiol 15(5):291-6.
Stahl W, Heinrich U, Jungmann H, Sies H & Tronnier H (2000) Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr 71(3):795-8.
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Syed DN, Malik A, Hadi N, Sarfaraz S, Afaq F & Mukhtar H (2006) Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochem Photobiol 82(2):398-405.
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Traynor NJ, McKenzie RC, Beckett GJ & Gibbs NK (2006) Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photimmunol Photomed 22(6):297-303.
Wu WB, Chiang HS, Fang JY, Chen SK, Huang CC, Hung CF. 2006 (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation. Life Sci 79(8):801-7.
Wu H, Guo H & Zhao R (2006) Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi 126(5):365-71.
Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y & Otsuka F (2004) Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 18(11):895-9.
Yasuoka S, Takata J, Karube Y, Katoh E, Tsuzuki T, Kizu J, Tsuchiya M & Kobayashi S (2005) Topical application of a novel, water-soluble gamma-tocopherol derivative prevents UV-induced skin damage in mice. Photochem Photobiol 81(4):908-13.
Yeh SL, Wang WY, Huang CH & Hu ML (2005) Pro-oxidative effect of beta-carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblast C3H10T1/2 cells. J Nutr Biochem 16(12):729-35.
Yoshida E, Watanabe T, Takata J, Yamazaki A, Karube Y & Kobayashi S (2006) Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. J Invest Dermatol 126(7):1633-40.
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Zhu J, Luo D, Shen CH & Xu J (2007) Photo-protection of epigallocatethi-3-gallate on aging and gene mutation of human skin fibroblasts caused by ultraviolet radiation: an in vitro experiment. Zhonghua Yi Xue Za Zhi 87(20):1398-401.
